Abstract | BACKGROUND AND OBJECTIVE: MATERIALS AND METHODS: Escalating light doses at 664 nm were applied focally to corneal neovascularization in rats 10 minutes following an intravenous injection of SnET2 using a low-power diode laser. Controls consisted of light-only and drug-only treatments. Clinical, angiographic, and histopathologic evaluations were performed on the animals up to 28 days after drug and/or light treatment. RESULTS: A drug and light dose-response was seen in producing neovessel closure. In animals treated with SnET2 and the highest light dose (25 J/cm2), all eyes showed occlusion at every follow-up evaluation up to 28 days. Control eyes demonstrated progressive disease at all time points. CONCLUSIONS:
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Authors | G B Primbs, R Casey, K Wamser, W J Snyder, D H Crean |
Journal | Ophthalmic surgery and lasers
(Ophthalmic Surg Lasers)
Vol. 29
Issue 10
Pg. 832-8
(Oct 1998)
ISSN: 1082-3069 [Print] United States |
PMID | 9793949
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Porphyrins
- Radiation-Sensitizing Agents
- tin etiopurpurin
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Topics |
- Animals
- Corneal Neovascularization
(drug therapy, pathology)
- Disease Models, Animal
- Dose-Response Relationship, Radiation
- Fluorescein Angiography
(methods)
- Male
- Microscopy, Video
(methods)
- Photochemotherapy
(methods)
- Porphyrins
(therapeutic use)
- Radiation-Sensitizing Agents
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
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