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Photodynamic therapy for corneal neovascularization.

AbstractBACKGROUND AND OBJECTIVE:
Photodynamic therapy with tin ethyl etiopurpurin (SnET2) was evaluated as a treatment modality for rat corneal neovascularization.
MATERIALS AND METHODS:
Escalating light doses at 664 nm were applied focally to corneal neovascularization in rats 10 minutes following an intravenous injection of SnET2 using a low-power diode laser. Controls consisted of light-only and drug-only treatments. Clinical, angiographic, and histopathologic evaluations were performed on the animals up to 28 days after drug and/or light treatment.
RESULTS:
A drug and light dose-response was seen in producing neovessel closure. In animals treated with SnET2 and the highest light dose (25 J/cm2), all eyes showed occlusion at every follow-up evaluation up to 28 days. Control eyes demonstrated progressive disease at all time points.
CONCLUSIONS:
Photodynamic therapy appears to be safe and effective for eliciting prolonged (> 28 days) occlusion of corneal neovascularization in the rat model with minimal side effects and good clinical outcomes.
AuthorsG B Primbs, R Casey, K Wamser, W J Snyder, D H Crean
JournalOphthalmic surgery and lasers (Ophthalmic Surg Lasers) Vol. 29 Issue 10 Pg. 832-8 (Oct 1998) ISSN: 1082-3069 [Print] United States
PMID9793949 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Porphyrins
  • Radiation-Sensitizing Agents
  • tin etiopurpurin
Topics
  • Animals
  • Corneal Neovascularization (drug therapy, pathology)
  • Disease Models, Animal
  • Dose-Response Relationship, Radiation
  • Fluorescein Angiography (methods)
  • Male
  • Microscopy, Video (methods)
  • Photochemotherapy (methods)
  • Porphyrins (therapeutic use)
  • Radiation-Sensitizing Agents (therapeutic use)
  • Rats
  • Rats, Sprague-Dawley

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