Dysplastic neocortex and subcortical heterotopias in methylazoxymethanol-treated rats: an intracellular study of identified pyramidal neurones.

Abstract	Intracellular recordings were obtained using biocytin-filled electrodes from 78 neurones located in both dysplastic neocortex and subcortical heterotopic aggregates in a model of neuronal migration disorder induced in rats by means of a double methylazoxymethanol injection given on embryonic day 15. Both regular spiking and intrinsically bursting pyramidal neurones were found in all of the examined structures and were synaptically activated by subcortical stimulation. In a neuronal subpopulation (22%) located in the neocortex as well as in the subcortical heterotopic aggregates, the injection of depolarising current pulses elicited aberrant firing patterns, consisting of repetitive bursts of APs that gradually increased in duration and eventually merged in a long-lasting discharge. The gradual development of this 'excessive' bursting behaviour suggests a progressive run-down of the slow components of the hyperpolarising afterpotential.
Authors	G Sancini, S Franceschetti, G Battaglia, C Colacitti, M Di Luca, R Spreafico, G Avanzini
Journal	Neuroscience letters (Neurosci Lett) Vol. 246 Issue 3 Pg. 181-5 (May 01 1998) ISSN: 0304-3940 [Print] Ireland
PMID	9792622 (Publication Type: Journal Article)
Chemical References	Methylazoxymethanol Acetate methylazoxymethanol
Topics	Animals Cell Movement (drug effects) Cerebral Ventricles (drug effects, pathology, physiology) Choristoma (physiopathology) Culture Techniques Drug Administration Schedule Electric Stimulation Embryo, Mammalian (drug effects) Evoked Potentials (drug effects, physiology) Female Hippocampus (drug effects, pathology, physiology) Injections, Intraperitoneal Intracellular Fluid (physiology) Maternal Exposure Maternal-Fetal Exchange Membrane Potentials (physiology) Methylazoxymethanol Acetate (administration & dosage, analogs & derivatives, pharmacology) Microelectrodes Neocortex (drug effects, pathology, physiopathology) Neurons (classification, drug effects, physiology) Pregnancy Pyramidal Cells (drug effects, pathology, physiology) Rats Synaptic Transmission (drug effects, physiology) Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!