Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors.

Abstract

PURPOSE:

The activity of vinorellbine, a new semisynthetic vinca alkaloid, was evaluated against a battery of human tumor xenografts derived from adult and pediatric CNS malignancies.

METHODS:

Tumors included adult high-grade gliomas (D-54 MG, D-245 MG), childhood high-grade gliomas (D-212 MG, D-456 MG), medulloblastomas (D-341 MED, D-487 MED), ependymomas (D-612 EP, D-528 EP), and a mismatch repair-deficient procarbazine-resistant glioma [D-245 MG (PR)]. Tumors were grown subcutaneously in athymic nude mice and vinorelbine was administered at a dose of 11 mg/kg on days 1, 5, and 9. Additionally, vinorelbine was also administered in combination with BCNU against D-54 MG.

RESULTS:

Vinorelbine produced statistically significant growth delays in D-456 MG, D-245 MG, and D-245 MG (PR). No statistically significant growth delays were observed in D-54 MG, D-487 MED, D-212 MG, D-528 EP, D-341 MED or D-612 EP. The antitumor effects of the vinorelbine/BCNU combination were additive. Growth delays observed in the procarbazine-resistant line [D-245 MG (PR)] were greater than twofold the delays seen in the parent line (D-245 MG). Vincristine was equally potent against D-245 MG and D-245 MG (PR). Taxol demonstrated little activity against D-245 MG but produced 32- and 18-day growth delays in D245 MG (PR).

CONCLUSIONS:

These studies indicate that vinorelbine possesses antitumor activity against several glioma tumor xenografts with marked activity in a mismatch repair deficient-tumor.

• Authors: M L Hanley, G B Elion, O M Colvin, P L Modrich, S Keir, D J Adams, D D Bigner, H S Friedman
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 42 Issue 6 Pg. 479-82 ( 1998) ISSN: 0344-5704 [Print] Germany
• PMID: 9788574 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Vinblastine
• Vinorelbine

Topics

• Adult
• Animals
• Antineoplastic Agents, Phytogenic (therapeutic use)
• Brain Neoplasms (drug therapy, genetics)
• Child
• Female
• Glioma (drug therapy, genetics)
• Humans
• Mice
• Mice, Inbred BALB C
• Neoplasm Transplantation
• Vinblastine (analogs & derivatives, therapeutic use)
• Vinorelbine