Abstract | OBJECTIVE: MATERIAL AND METHODS: RESULTS: Four patients required permanent pacemaker implantation during the first month postoperatively because of bradycardia; more than 2 years later, another patient required a permanent pacemaker because of sick sinus syndrome. In addition, one patient had an automatic implantable cardioverter-defibrillator. Three patients required reconstruction of cardiovascular structures with use of prosthetic material ( Teflon patches or donor tissue) at the time of cardiac transplantation. Actuarial 1-, 2-, and 5-year survival was 86.2 +/- 9.1%. During the first year after transplantation, two deaths occurred--one at 41 days of putative vascular rejection and the second at 60 days of severe cellular rejection. All other patients are alive and functionally rehabilitated; the mean follow-up period has been 26.1 months (range, 2 to 89.6). CONCLUSION:
Cardiac transplantation for patients with congenital heart disease can be accomplished with a low perioperative mortality and an excellent medium-term survival despite the challenges presented by the technical difficulties during invasive diagnostic procedures and at operation and the need for adherence to long-term multiple- drug therapy in this patient population.
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Authors | G Speziali, D J Driscoll, G K Danielson, P R Julsrud, C J Porter, J A Dearani, R C Daly, C G McGregor |
Journal | Mayo Clinic proceedings
(Mayo Clin Proc)
Vol. 73
Issue 10
Pg. 923-8
(Oct 1998)
ISSN: 0025-6196 [Print] England |
PMID | 9787738
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Actuarial Analysis
- Adolescent
- Adult
- Child
- Child, Preschool
- Female
- Graft Survival
- Heart Defects, Congenital
(surgery)
- Heart Transplantation
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Middle Aged
- Reoperation
- Survival Analysis
- Treatment Outcome
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