Granulocytic sarcoma presented as a reactivation of chronic myeloid leukemia after allogenic marrow transplantation.

Abstract

The authors report the case of a chronic myeloid leukemia (CML) patient submitted to allogenic bone marrow transplantation, who had probably never entered complete remission. The disease was reactivated as a granulocytic sarcoma, next to a platinum plate installed to correct a tibia fracture 11 years earlier. Its final event was a myeloid Ph1 + blastic crisis that was unsuccessfully treated with high doses of sc interferon and citarabine.

• Authors: J S de Oliveira, M de L Chauffaille, G W Colleoni, V M Morelli, O M Hauache, V N Alberti, J Kerbauy
• Journal: Sao Paulo medical journal = Revista paulista de medicina (Sao Paulo Med J) 1998 Mar-Apr Vol. 116 Issue 2 Pg. 1689-91 ISSN: 1516-3180 [Print] Brazil
• PMID: 9778890 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Cytarabine
• Interferons

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Blast Crisis (drug therapy)
• Bone Marrow Transplantation (adverse effects)
• Cytarabine (therapeutic use)
• Fatal Outcome
• Female
• Humans
• Interferons (therapeutic use)
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (etiology, pathology, therapy)
• Leukemia, Myeloid (etiology)
• Recurrence