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Tazarotene in combination with phototherapy.

Abstract
Despite the vast array of available therapies for treating psoriasis, there remains a need for safer, more effective treatments. Topical tazarotene has been shown to be effective in treating mild-to-moderate psoriasis without causing the adverse effects, such as mucocutaneous toxicity, hyperostosis, and elevation in serum lipids, often associated with orally administered retinoids. A 2-week pretreatment with tazarotene 0.1% gel once daily, followed by tazarotene plus UVB therapy (tazarotene-UVB) 3 times per week for 10 weeks, was more effective than UVB therapy alone or in combination with vehicle gel in reducing plaque elevation, scaling, and erythema. The tazarotene-UVB treatment was well tolerated, and no phototoxicity was observed. Treatment success, defined as a moderate response or better in psoriatic lesions (ie, > or = 50% improvement in psoriatic lesions compared with baseline), was achieved within 32 days with the tazarotene-UVB treatment, compared with 67 days with UVB alone or UVB plus vehicle gel.
AuthorsJ Y Koo
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 39 Issue 4 Pt 2 Pg. S144-8 (Oct 1998) ISSN: 0190-9622 [Print] United States
PMID9777793 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Keratolytic Agents
  • Nicotinic Acids
  • tazarotene
Topics
  • Administration, Cutaneous
  • Humans
  • Keratolytic Agents (therapeutic use)
  • Nicotinic Acids (therapeutic use)
  • Photochemotherapy
  • Psoriasis (drug therapy)
  • Randomized Controlled Trials as Topic
  • Ultraviolet Therapy

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