Tazarotene in combination with topical corticosteroids.

Abstract

The use of a topical corticosteroid in combination with tazarotene has theoretic appeal because each drug has a different mechanism of action, and it is therefore likely that combination therapy will offer additive or synergistic effects. For example, the steroid may promote a rapid initial response together with minimization of erythema during the treatment period, and tazarotene may prolong the duration of the therapeutic effect and lower the probability of relapse. The results of a large, controlled clinical trial in which corticosteroids of various potencies were added to tazarotene therapy showed that tazarotene plus a medium- or high potency corticosteroid produced greater and more rapid efficacy, and superior tolerability, than tazarotene plus placebo cream.

• Authors: M Lebwohl, Y Poulin
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 39 Issue 4 Pt 2 Pg. S139-43 (Oct 1998) ISSN: 0190-9622 [Print] United States
• PMID: 9777792 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Adrenal Cortex Hormones
• Keratolytic Agents
• Nicotinic Acids
• tazarotene

Topics

• Administration, Cutaneous
• Adrenal Cortex Hormones (therapeutic use)
• Clinical Trials as Topic
• Drug Synergism
• Drug Therapy, Combination
• Humans
• Keratolytic Agents (therapeutic use)
• Nicotinic Acids (therapeutic use)
• Psoriasis (drug therapy, pathology)