Rheumatoid nodules of the larynx.

A 67-year-old woman with rheumatoid arthritis was hospitalized because of dysphagia and severe nodulosis. Over a two-year period the patient had been treated with methotrexate. A computed tomography (CT) scan of the neck showed a 2 x 2 cm large tumour behind the top left lateral thyroid cartilage. A biopsy taken during direct laryngoscopy showed it was a rheumatic nodule. Treatment with colchicine reduced the patient's dysphagia. As methotrexate is used increasingly in the treatment of rheumatoid arthritis and as this particular drug causes rheumatic nodules in five to 10 per cent of the patients, it must be foreseen that the incidence of nodules in the upper airways will increase.
AuthorsW T Sørensen, K Møller-Andersen, N Behrendt
JournalThe Journal of laryngology and otology (J Laryngol Otol) Vol. 112 Issue 6 Pg. 573-4 (Jun 1998) ISSN: 0022-2151 [Print] ENGLAND
PMID9764301 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antirheumatic Agents
  • Gout Suppressants
  • Colchicine
  • Methotrexate
  • Aged
  • Antirheumatic Agents (adverse effects)
  • Colchicine (therapeutic use)
  • Female
  • Gout Suppressants (therapeutic use)
  • Humans
  • Laryngeal Diseases (chemically induced, drug therapy, radiography)
  • Laryngoscopy
  • Methotrexate (adverse effects)
  • Rheumatic Nodule (chemically induced, drug therapy, radiography)
  • Tomography, X-Ray Computed

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