Abstract | AIM: After a misdiagnosis of pulmonary adenocarcinoma as desquamative interstitial pneumonia (DIP), we investigated whether immunohistochemical markers could differentiate these conditions. METHODS AND RESULTS: Three cases of DIP and one pulmonary adenocarcinoma masquerading as DIP were studied by light and electron microscopy. All cases were mucin-negative. The cases of DIP were CD68 positive but cytokeratin-negative. The adenocarcinoma was cytokeratin-positive (AE1/3 and CAM5.2), as well as showing some CD68-positive cells. Markers for carcinoma (CEA, Ber-EP4, and Leu M1) were negative in all cases. Ultrastructurally the adenocarcinoma appeared to be derived from Type II pneumocytes. CONCLUSION: Before a diagnosis of DIP is made, cytokeratin markers should be used.
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Authors | A E Mutton, P S Hasleton, A Curry, P W Bishop, J Egan, K B Carroll, S Hanley |
Journal | Histopathology
(Histopathology)
Vol. 33
Issue 2
Pg. 129-35
(Aug 1998)
ISSN: 0309-0167 [Print] England |
PMID | 9762545
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adenocarcinoma
(chemistry, pathology, ultrastructure)
- Adult
- Biomarkers
(analysis)
- Diagnosis, Differential
- Fatal Outcome
- Female
- Humans
- Immunohistochemistry
- Lung
(chemistry, ultrastructure)
- Lung Diseases, Interstitial
(pathology)
- Lung Neoplasms
(chemistry, pathology, ultrastructure)
- Male
- Microscopy, Electron
- Middle Aged
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