A double-blind, placebo-controlled study of intranasal apomorphine spray as a rescue agent for off-states in Parkinson's disease.

Nine patients with advanced levodopa-responsive Parkinson's disease were enrolled in a double-blind, placebo-controlled crossover trial of intranasal apomorphine as rescue therapy for parkinsonian off-states. Patients were assigned in random order to each of four possible combinations of apomorphine, trimethobenzamide antiemetic, and their matched placebos and received detailed in-office motor scoring during each of the four study periods. Patients also completed diaries describing the effectiveness of the nasal spray for reversing off-states. A statistically significant reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score was seen following active apomorphine during in-office evaluation visits but not following placebo nasal spray. Patient diaries revealed that active apomorphine had a latency to onset of 11 minutes and a duration of 50 minutes. Significant nausea from apomorphine spray was seen in only one patient whereas nasal irritation was disabling in three and mild in two. We conclude that intranasal apomorphine is an effective rescue agent for parkinsonian off-states although nasal irritation is a limiting factor.
AuthorsR B Dewey Jr, D M Maraganore, J E Ahlskog, J Y Matsumoto
JournalMovement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 13 Issue 5 Pg. 782-7 (Sep 1998) ISSN: 0885-3185 [Print] UNITED STATES
PMID9756146 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Aerosols
  • Antiemetics
  • Antiparkinson Agents
  • Benzamides
  • Levodopa
  • Apomorphine
  • trimethobenzamide
  • Administration, Intranasal
  • Aerosols
  • Aged
  • Antiemetics (administration & dosage, adverse effects)
  • Antiparkinson Agents (administration & dosage, adverse effects)
  • Apomorphine (administration & dosage, adverse effects)
  • Benzamides (administration & dosage, adverse effects)
  • Cross-Over Studies
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Levodopa (administration & dosage, adverse effects)
  • Male
  • Middle Aged
  • Neurologic Examination (drug effects)
  • Parkinson Disease (drug therapy)
  • Pilot Projects
  • Premedication
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password:
Type Validation Code Shown: