[The concept of the clinical use of serotonin adipinate in treating surgical patients].

Abstract

The influence of serotonin adipinate on the mechanisms of development of tissue hypoxia, disturbances of the microcirculatory bed and smooth muscles before, during and after operative interventions was studied in experiments and clinical practice. The syndrome of serotonin insufficiency is described including smooth muscle insufficiency which can be abolished by serotonin adipinate administered at the early postoperative period irrespective of the cause of surgery, age and sex of the patient. Good results were obtained in treatment of patients after operations on the liver, pancrease, heart, in patients with the diabetic foot and in other diseases. No complications or lethal outcomes resulting from using serotonin adipinate were noted.

• Authors: V D Fedorov, A P Simonenkov
• Journal: Vestnik khirurgii imeni I. I. Grekova (Vestn Khir Im I I Grek) Vol. 157 Issue 3 Pg. 15-9 ( 1998) ISSN: 0042-4625 [Print] Russia (Federation)
• Vernacular Title: Kontseptsiia klinicheskogo primeneniia serotonina adipinata pri lechenii khirurgicheskikh bol'nykh.
• PMID: 9751961 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Adipates
• serotonin adipinate
• Serotonin

Topics

• Adipates (adverse effects, therapeutic use)
• Drug Evaluation
• Gastrointestinal Motility (drug effects)
• Humans
• Intestinal Obstruction (physiopathology, prevention & control)
• Postoperative Complications (physiopathology, prevention & control)
• Serotonin (adverse effects, analogs & derivatives, therapeutic use)