Transfer RNA species in tumors of different growth rates.

Tyrosyl-, histidyl-, lysyl-, and phenylalanyl-tRNA's from 3 tumors (DBAH, DBAH, and DBA), differing in growth rates and from host mammary glands and liver, were compared by means of methylated albumin kieselguhr (MAK) column and by reverse-phase-5 chromatography. The elution profiles of lysyl-tRNA's from DBAH and DBA, phenylalanyl Trna's from DBAH and DBAH, and histidyl-tRNA's from DBA3 tumors exhibited extra isoaccepting species, compared with host liver and mammary glands. The distribution of acylatable tyrosyl-tRNA's in DBA3 and DBAH, phenylalanyl-tRNA's in DBAH and DBAH2, and histid-l-tRNA's in DBA3 is higher than that in liver, whereas no appreciable differences were observed in the lysyl-tRNA contents of the tumors and liver. The chromatographic alternations appeared to be a property of the tumor tRNA's and not due to differences in aminoacyl-tRNA synthetases or due to the aggregation of tRNA's. The structural and functional significance of these findings are discussed.
AuthorsH Mukerjee, A Goldfeder
JournalCancer research (Cancer Res) Vol. 36 Issue 9 pt.1 Pg. 3330-8 (Sep 1976) ISSN: 0008-5472 [Print] United States
PMID975094 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • RNA, Neoplasm
  • Tyrosine
  • Phenylalanine
  • Histidine
  • RNA, Transfer
  • Lysine
  • Adenocarcinoma (metabolism)
  • Animals
  • Cell Division
  • Female
  • Histidine (metabolism)
  • Liver (metabolism)
  • Lymphoma (metabolism)
  • Lysine (metabolism)
  • Mammary Glands, Animal (metabolism)
  • Mammary Neoplasms, Experimental (metabolism)
  • Mice
  • Mice, Inbred DBA
  • Neoplasms, Experimental (metabolism)
  • Phenylalanine (metabolism)
  • RNA, Neoplasm (metabolism)
  • RNA, Transfer (metabolism)
  • Time Factors
  • Tyrosine (metabolism)

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