Abstract | AIM: To compare efficiency of the programs MCVP, VCAP and ARA-COP in the treatment of multiple myeloma (MM) as regards completeness of the response, duration of the remission and toxicity. MATERIALS AND METHODS: A total of 41 MM patients entered the study (27 females, 14 males, age from 41 to 72 years, MM duration from 1 month to 8 years). 16, 10 and 15 patients were treated according to MCVP, VCAP and ARA-COP programs. RESULTS: Both in the resistant and primary patients the response was the highest to ARA-COP treatment. The remission or stabilization was achieved in 93.4% of patients. VCAP program was less effective. However, clinicohematological remission was achieved in 50% of patients. This program is rather heart toxic. MCVP program was the least effective. Survival was followed up in 16 patients (10 MCVP, 3 VCAP and 3 ARA-COP patients). The survival was 20-62, 16-36, 23.6-64.8 months for ARA-COP, VCAP and MCVP, respectively. CONCLUSION: ARA-COP program proved most effective of the three programs both in primary and drug-resistant patients. VCAP and MCVP programs are less effective but can be used in primary management of MM patients.
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Authors | S S Bessmel'tsev, K M Abdulkadyrov, O A Rukavitsyn |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 70
Issue 7
Pg. 46-9
( 1998)
ISSN: 0040-3660 [Print] Russia (Federation) |
Vernacular Title | Effektivnost' nekotorykh programm polikhimioterapii pri lechenii bol'nykh mnozhestvennoĭ mielomoĭ. |
PMID | 9742636
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Cytarabine
- Vincristine
- Doxorubicin
- Cyclophosphamide
- Prednisolone
- Melphalan
- Prednisone
|
Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Cyclophosphamide
(administration & dosage)
- Cytarabine
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Drug Evaluation
- Female
- Humans
- Male
- Melphalan
(administration & dosage)
- Middle Aged
- Multiple Myeloma
(drug therapy)
- Prednisolone
(administration & dosage)
- Prednisone
(administration & dosage)
- Remission Induction
- Vincristine
(administration & dosage)
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