Abstract |
Combination therapy consisting of high-dose pyridoxal phosphate (40-50 mg/kg/day) and low-dose synthetic ACTH (0.01 mg/kg/day) was prescribed in 28 children with infantile spasms. Monotherapy with pyridoxal phosphate provided excellent seizure control in 3 of the 28 (11%) patients. ACTH was subsequently added to the regimen of the remaining 25 patients. As of 1 month after discontinuing the ACTH treatment, 21 of the 25 (84%) patients had experienced no seizures. The mean interval until seizure control was achieved was 4.1 days after the start of treatment with ACTH. The 21 patients have been monitored for a mean of 34.9 months (range 2-81 months); 6 patients (29%) have had recurrences of infantile spasms, and 10 (48%) have experienced normal development. Fourteen of the 28 patients (50%) have had transient increases in liver enzymes, but none of the patients developed more serious side effects.
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Authors | Y Takuma |
Journal | Epilepsia
(Epilepsia)
Vol. 39 Suppl 5
Pg. 42-5
( 1998)
ISSN: 0013-9580 [Print] United States |
PMID | 9737444
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anticonvulsants
- Cosyntropin
- Pyridoxal Phosphate
- Pyridoxine
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Topics |
- Age of Onset
- Anticonvulsants
(administration & dosage, therapeutic use)
- Child, Preschool
- Cosyntropin
(administration & dosage, therapeutic use)
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Humans
- Infant
- Male
- Pyridoxal Phosphate
(administration & dosage, therapeutic use)
- Pyridoxine
(therapeutic use)
- Recurrence
- Spasms, Infantile
(drug therapy)
- Treatment Outcome
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