Experimentally induced osteoarthrosis in the temporomandibular joint of the mouse.

Abstract

(1) 6-week-old ICR mice were injected daily with pharmacologic doses of triamcinolone diacetate (1.5 mg/kg body weight) for 8 consecutive weeks. (2) The temporomandibular joint served as a model for histological and histochemical examinations concerning the effect of glucocorticoid hormone upon bone and cartilage. (3) Histochemical reactions indicated a large number of lipid droplets within the peripheral vasculature. (4) Histological examinations revealed pathologic features, indicative of primary osteoarthrosis.

• Authors: M Silbermann
• Journal: Acta anatomica (Acta Anat (Basel)) Vol. 96 Issue 1 Pg. 9-24 ( 1976) ISSN: 0001-5180 [Print] Switzerland
• PMID: 973542 (Publication Type: Journal Article)

Chemical References

• Triamcinolone

Topics

• Animals
• Cartilage, Articular (drug effects, metabolism, pathology)
• Female
• Lipid Metabolism
• Male
• Mandibular Condyle (drug effects, metabolism, pathology)
• Mice
• Mice, Inbred Strains
• Osteoarthritis (chemically induced, metabolism, pathology)
• Temporomandibular Joint (drug effects, metabolism, pathology)
• Triamcinolone