[Results of combination therapy of UFT-E with low-dose CDDP for patients with advanced recurrent breast cancer].

Abstract

CDDP, as a modulator for 5-FU, has already been described as a very effective treatment for gastrointestinal tract cancer. We administered a dose of 400 mg of UFT-E orally every day, and 10 mg of CDDP by drip infusion twice weekly, for more than 10 weeks to 12 outpatients with metastatic local, pulmonary, hepatic, osteal or multiple-organ cancer which showed a poor response to the pretreatment, and assessed its efficacy and drug toxicity. In terms of the clinical efficacy of this therapy, CR was noted in one patient and PR in 2 patients with a response rate of 25%. The incidence of drug toxicity was low. Complications included temporal transient nausea and anorexia in two patients and leukopenia grade 2 as bone marrow suppression in 3 patients. From the standpoint of QOL, as well as in terms of both antitumor effect and drug toxicity, the therapy mentioned above was believed to be effective for outpatients with advanced recurrent breast cancer.

• Authors: T Ito, M Yamada, H Tanemura, H Oshita, M Asano, S Saji
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 25 Issue 10 Pg. 1575-80 (Aug 1998) ISSN: 0385-0684 [Print] Japan
• PMID: 9725051 (Publication Type: English Abstract, Journal Article)

Chemical References

• Tegafur
• Uracil
• Cisplatin

Topics

• Administration, Oral
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bone Neoplasms (drug therapy, secondary)
• Breast Neoplasms (drug therapy, pathology)
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Female
• Humans
• Infusions, Intravenous
• Lung Neoplasms (drug therapy, secondary)
• Middle Aged
• Tegafur (administration & dosage)
• Uracil (administration & dosage)