Abstract | PURPOSE: METHODS: Early (4-9 h postinfection, PI) and late (10-15 h PI) therapies were studied, employing 5 groups: ciprofloxacin-PSS, ciprofloxacin, ofloxacin, PSS vehicle. and untreated. Dosing regimens were: every 30 min, 60 min, or a single drop applied at 9 h PI. Eyes were observed by slit lamp examination (SLE) and bacterial colony forming units (CFU) per cornea were determined. RESULTS: CONCLUSIONS:
|
Authors | J M Moreau, L C Green, L S Engel, J M Hill, R J O'Callaghan |
Journal | Current eye research
(Curr Eye Res)
Vol. 17
Issue 8
Pg. 808-12
(Aug 1998)
ISSN: 0271-3683 [Print] England |
PMID | 9723996
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Anti-Infective Agents
- Ophthalmic Solutions
- Polystyrenes
- Ciprofloxacin
- polystyrene sulfonic acid
- Ofloxacin
|
Topics |
- Animals
- Anti-Infective Agents
(therapeutic use)
- Ciprofloxacin
(analogs & derivatives, therapeutic use)
- Colony Count, Microbial
- Cornea
(microbiology)
- Disease Models, Animal
- Drug Delivery Systems
- Eye Infections, Bacterial
(drug therapy, microbiology)
- Keratitis
(drug therapy, microbiology)
- Ofloxacin
(therapeutic use)
- Ophthalmic Solutions
- Polystyrenes
(therapeutic use)
- Rabbits
- Staphylococcal Infections
(drug therapy, microbiology)
- Staphylococcus aureus
(growth & development)
|