Abstract | BACKGROUND AND OBJECTIVES:
Proteoglycans of the extracellular matrix are vital to the growth and evolution of malignant neoplasms. The present study determined the composition of proteoglycans isolated from paired specimens of normal breast and adenocarcinoma of the breast harvested from each patient (n = 8). The proteoglycans were then tested for their ability to stimulate endothelial cell proliferation. METHODS: RESULTS: CONCLUSIONS: These results indicate that malignant breast tissue exhibits both qualitative and quantitative changes in proteoglycan composition, which, in turn, may stimulate endothelial cell proliferation.
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Authors | P Vijayagopal, J E Figueroa, E A Levine |
Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 68
Issue 4
Pg. 250-4
(Aug 1998)
ISSN: 0022-4790 [Print] United States |
PMID | 9721712
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adenocarcinoma
(chemistry, pathology)
- Aged
- Aged, 80 and over
- Breast
(chemistry, cytology)
- Breast Neoplasms
(chemistry, pathology)
- Carcinoma, Ductal, Breast
(chemistry, pathology)
- Cell Division
(physiology)
- Endothelium
(cytology)
- Female
- Humans
- Middle Aged
- Proteoglycans
(isolation & purification, metabolism)
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