Abstract | PURPOSE: MATERIALS AND METHODS: A total of 53 pediatric urologists and/or pediatric surgeons at 41 centers worldwide answered an inquiry regarding experience with subureteral polytetrafluoroethylene injection in vesicoureteral reflux. Data were collected from a completed standard questionnaire. From 1984 to 1996, 1,921 boys and 6,411 girls with a mean age of 4.5 years (12,251 refluxing ureters) were treated endoscopically with subureteral polytetrafluoroethylene injection. Reflux was grades I to V in 407 (3.3%), 3,832 (31.2%), 5,213 (42.5%), 2,218 (18.1%) and 581 (4.7%) ureters, respectively. In the majority of patients subureteral polytetrafluoroethylene injection was performed on an outpatient basis. Most urologists monitored patients with voiding cystourethrography and renal ultrasound at 3 months, 1 year and 3 years. All patients were followed 1 to 13 years. RESULTS: Reflux resolved in 9,226 ureters (75.3%) after 1 polytetrafluoroethylene injection, in 1,478 (12%) after 2 and in 250 (2%) after 3 or 4. Vesicoureteral reflux improved to grade I after 1 or 2 injections in 743 (6%) ureters, which needed no further treatment. Subureteral injection failed to correct reflux in 554 ureters (4.5%), which were then treated with ureteral reimplantation. Vesicoureteral junction obstruction requiring ureteral reimplantation developed in 41 ureters (0.33%). More than 90% of patients have been followed for more than 2 years. At followup reflux recurred in 326 (2.8%) endoscopically corrected refluxing ureters. No clinically untoward effects were reported in any patient due to the use of polytetrafluoroethylene as an injectable material. CONCLUSIONS:
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Authors | P Puri, C Granata |
Journal | The Journal of urology
(J Urol)
Vol. 160
Issue 3 Pt 2
Pg. 1007-11; discussion 1038
(Sep 1998)
ISSN: 0022-5347 [Print] United States |
PMID | 9719265
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
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Topics |
- Adolescent
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Humans
- Infant
- Injections
- Male
- Polytetrafluoroethylene
(therapeutic use)
- Surveys and Questionnaires
- Ureter
- Ureteroscopy
- Vesico-Ureteral Reflux
(therapy)
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