Histopathological and immunohistochemical studies of intracranial nervous-system tumours in four cattle.

Abstract

Intracranial nervous-system tumours were diagnosed in three of 1092 bovine necropsy specimens submitted to the Department of Veterinary Pathology, Obihiro University between April 1983 and March 1996. A fourth case was a referral from the Department of Veterinary Pathology, Rakuno Gakuen University. Histopathological examination revealed four types of tumour: intracranial malignant peripheral nerve sheath tumour (MPNST), choroid plexus papilloma, differentiated fibrillary astrocytoma and anaplastic (malignant) astrocytoma. Immunohistochemically, the intracranial MPNST was strongly positive for S-100 protein and vimentin, and in places weakly positive for glial fibrillary acid protein (GFAP). The choroid plexus papilloma was strongly positive for epithelial membrane antigen (EMA), keratin, S-100 protein and vimentin, and positive for GFAP in places. The cytoplasm and fibrous component in the differentiated fibrillary astrocytoma were strongly positive for S-100 protein and GFAP. The anaplastic (malignant) astrocytoma was strongly positive for vimentin, S-100 protein and keratin in the cytoplasm and fibrous processes, and weakly positive for GFAP and EMA in places. Myelin basic protein (MBP) and synaptophysin showed a weak positive reaction in the marginal areas of the tumour.

• Authors: M Yamada, M Nakagawa, M Yamamoto, H Furuoka, T Matsui, H Taniyama
• Journal: Journal of comparative pathology (J Comp Pathol) Vol. 119 Issue 1 Pg. 75-82 (Jul 1998) ISSN: 0021-9975 [Print] England
• PMID: 9717129 (Publication Type: Journal Article)

Chemical References

• Glial Fibrillary Acidic Protein
• Mucin-1
• Myelin Basic Protein
• S100 Proteins
• Vimentin
• Keratins

Topics

• Animals
• Astrocytoma (chemistry, pathology, veterinary)
• Brain Neoplasms (chemistry, pathology, veterinary)
• Cattle
• Cattle Diseases (metabolism, pathology)
• Glial Fibrillary Acidic Protein (analysis)
• Glioblastoma (chemistry, pathology, veterinary)
• Glioma (chemistry, pathology, veterinary)
• Immunohistochemistry
• Keratins (analysis)
• Mucin-1 (analysis)
• Myelin Basic Protein (analysis)
• Nerve Sheath Neoplasms (pathology, veterinary)
• S100 Proteins (analysis)
• Vimentin (analysis)