Abstract |
We examined the elevation of glutathione (GSH) levels in the liver of C57BL/6 female mice after low-dose r-ray irradiation and its inhibitory effect on CClI4-induced liver damage. The liver GSH level increased soon after irradiation with 50 cGy of gamma-rays, reached a maximum at around 12 post-treatment, and returned almost to the control level by 24 h. The activities of glutathione reductase, and glutathione peroxidase also showed the same pattern of change, while the activity of gamma-glutamylcysteine synthetase showed a gradual increase up to 24 h. The effect of pre-irradiation on CCl4-induced liver damage was also investigated. The activities of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in serum were markedly increased 12 h post-treatment with CCl4. Both increases were significantly suppressed by a single low-dose pre-irradiation. Malondialdehyde, a marker of lipidperoxidation, was also greatly elevated after CCl4 treatment, and its increase was suppressed by irradiation. These results suggest low-dose gamma-ray irradiation might be effective for the prevention of and/or therapy of various reactive oxygen species-related diseases including cancer.
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Authors | S Kojima, O Matsuki, T Nomura, A Kubodera, K Yamaoka |
Journal | Anticancer research
(Anticancer Res)
1998 Jul-Aug
Vol. 18
Issue 4A
Pg. 2471-6
ISSN: 0250-7005 [Print] Greece |
PMID | 9703894
(Publication Type: Journal Article)
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Chemical References |
- Glutathione Peroxidase
- Glutathione Reductase
- Glutamate-Cysteine Ligase
- Glutathione
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Topics |
- Animals
- Carbon Tetrachloride Poisoning
(metabolism, pathology)
- Female
- Gamma Rays
- Glutamate-Cysteine Ligase
(metabolism, radiation effects)
- Glutathione
(metabolism, radiation effects)
- Glutathione Peroxidase
(metabolism, radiation effects)
- Glutathione Reductase
(metabolism, radiation effects)
- Kinetics
- Liver
(metabolism, pathology, radiation effects)
- Mice
- Mice, Inbred C57BL
- Time Factors
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