[Influence of uncoupling agents on the capacity of transamidinase in kidney and pancreas].

Abstract

It was found in white rats that hyperthyreosis (0.5% thyreoidin in dry food), respectively 2,4-dinitrophenol (30 mg/kg body weight/day i. p.), deficiency of the vitamins K and E or complete fasting increase the content of creatine in muscle, plasma and urine, but reduce the concentration of creatinine. Simultaneously the elevated creatine level of blood causes a repression of transamidinase in kidneys and pancreas. The common mode of action of the mentioned agents is seen in a decoupling of the oxidative phosphorylation, and in an insufficient availability of ATP, respectively.

• Authors: J Methfessel, I Rodina
• Journal: Acta biologica et medica Germanica (Acta Biol Med Ger) Vol. 35 Issue 3-4 Pg. 317-23 ( 1976) ISSN: 0001-5318 [Print] Germany
• Vernacular Title: Einfluss entkoppelnder Agentien auf die Transamidinase-Kapazität von Nieren und Pankreas
• PMID: 970042 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dinitrophenols
• Uncoupling Agents
• Adenosine Triphosphate
• Creatinine
• Amidinotransferases
• Creatine

Topics

• Adenosine Triphosphate (metabolism)
• Amidinotransferases (metabolism)
• Animals
• Creatine (metabolism)
• Creatinine (metabolism)
• Dinitrophenols (pharmacology)
• Fasting
• Hyperthyroidism (enzymology)
• Kidney (drug effects, enzymology)
• Oxidative Phosphorylation (drug effects)
• Pancreas (drug effects, enzymology)
• Rats
• Uncoupling Agents (pharmacology)
• Vitamin E Deficiency (enzymology)
• Vitamin K Deficiency (enzymology)