Use of an oral antiseptic bioadhesive tablet in dogs.

V3703 (Stomadhex) is a tablet with bioadhesive properties enabling it to remain in place for several hours after it has been placed on the oral mucosa. It continuously releases chlorhexidine and niacinamide. In a study conducted in 15 dogs, the tablets were well tolerated by the animals. The product significantly reduced (p < 0.05): dental plaque; quantitative periodontopathogen and total anaerobic bacterial counts; spirochetes; and halitosis when used daily over a 14 day period. Gingivitis was also reduced, though not significantly (p = 0.07). Stomadhex treatment can provide a carry-over effect following dental scaling by reducing oral microflora and retarding the reappearance of dental plaque.
AuthorsP Gruet, C Gaillard, B Boisramé, D Duffaut, A M Grimoud, G Camy
JournalJournal of veterinary dentistry (J Vet Dent) Vol. 12 Issue 3 Pg. 87-91 (Sep 1995) ISSN: 0898-7564 [Print] UNITED STATES
PMID9693631 (Publication Type: Journal Article)
Chemical References
  • Anti-Infective Agents, Local
  • Drug Combinations
  • Tablets
  • Niacinamide
  • Chlorhexidine
  • Administration, Topical
  • Analysis of Variance
  • Animals
  • Anti-Infective Agents, Local (administration & dosage)
  • Bacteria, Anaerobic (drug effects)
  • Chlorhexidine (administration & dosage)
  • Colony Count, Microbial
  • Dental Plaque (drug therapy, microbiology, veterinary)
  • Dog Diseases (drug therapy, microbiology)
  • Dogs
  • Drug Combinations
  • Gingivitis (drug therapy, veterinary)
  • Halitosis (drug therapy, veterinary)
  • Linear Models
  • Mouth Mucosa
  • Niacinamide (administration & dosage)
  • Spirochaetales (drug effects)
  • Tablets

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