Abstract |
Whether or not ROS are the actual initiator or a downstream mediator of stunning, the theory that they play a major causative role in this phenomenon is now a proven hypothesis. ROS play a prominent role in multiple forms of stunning. Furthermore, the role of ROS is prominent not only in open-chest models but also in conscious animal preparations. The major challenge for future studies will be to identify the specific molecular targets of ROS-mediated damage and to decipher the pathways whereby ROS and calcium interact in the genesis of myocardial stunning.
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Authors | R Bolli |
Journal | Basic research in cardiology
(Basic Res Cardiol)
Vol. 93
Issue 3
Pg. 156-62
(Jun 1998)
ISSN: 0300-8428 [Print] Germany |
PMID | 9689438
(Publication Type: Comparative Study, Congress, Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
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Topics |
- Animals
- Humans
- Myocardial Contraction
- Myocardial Stunning
(etiology, metabolism)
- Myocardium
(metabolism)
- Reactive Oxygen Species
(metabolism)
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