HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Causative role of oxyradicals in myocardial stunning: a proven hypothesis. A brief review of the evidence demonstrating a major role of reactive oxygen species in several forms of postischemic dysfunction.

Abstract
Whether or not ROS are the actual initiator or a downstream mediator of stunning, the theory that they play a major causative role in this phenomenon is now a proven hypothesis. ROS play a prominent role in multiple forms of stunning. Furthermore, the role of ROS is prominent not only in open-chest models but also in conscious animal preparations. The major challenge for future studies will be to identify the specific molecular targets of ROS-mediated damage and to decipher the pathways whereby ROS and calcium interact in the genesis of myocardial stunning.
AuthorsR Bolli
JournalBasic research in cardiology (Basic Res Cardiol) Vol. 93 Issue 3 Pg. 156-62 (Jun 1998) ISSN: 0300-8428 [Print] Germany
PMID9689438 (Publication Type: Comparative Study, Congress, Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Reactive Oxygen Species
Topics
  • Animals
  • Humans
  • Myocardial Contraction
  • Myocardial Stunning (etiology, metabolism)
  • Myocardium (metabolism)
  • Reactive Oxygen Species (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: