Preoperative oral granisetron prevents postoperative nausea and vomiting.

Postoperative nausea and vomiting (PONV) is a commonly observed adverse effect of anaesthesia. This study was designed to evaluate the efficacy of granisetron administered orally for preventing PONV in female patients undergoing major gynaecological surgery.
In a prospective, randomized, placebo-controlled, double-blind study, 120 patients received orally either placebo or granisetron (1 mg, 2 mg or 4 mg) (n = 30 for each) 1 h before surgery. The same standard general plus regional anaesthetic technique was employed throughout. Postoperatively, during the first 24 h after anaesthesia, the incidence of PONV and adverse events was recorded by nursing staff.
The incidence of PONV was 47% with placebo, 37% with granisetron 1 mg, 10% with granisetron 2 mg and 10% with granisetron 4 mg (P < 0.05; overall Fisher's exact probability test). No difference in the incidence of adverse events was observed among the groups.
Preoperative oral granisetron in a minimum dose of 2 mg is effective for preventing PONV after major gynaecological surgery.
AuthorsY Fujii, H Tanaka, H Toyooka
JournalActa anaesthesiologica Scandinavica (Acta Anaesthesiol Scand) Vol. 42 Issue 6 Pg. 653-7 (Jul 1998) ISSN: 0001-5172 [Print] DENMARK
PMID9689270 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Retracted Publication)
Chemical References
  • Antiemetics
  • Granisetron
  • Administration, Oral
  • Adult
  • Anesthesia (adverse effects)
  • Antiemetics (administration & dosage, adverse effects)
  • Double-Blind Method
  • Female
  • Granisetron (administration & dosage, adverse effects)
  • Gynecologic Surgical Procedures (adverse effects)
  • Humans
  • Middle Aged
  • Nausea (etiology, prevention & control)
  • Postoperative Complications (prevention & control)
  • Premedication
  • Prospective Studies
  • Vomiting (etiology, prevention & control)

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