Abstract | BACKGROUND/AIMS: METHODOLOGY: Twenty-six consecutive symptomatic H. pylori-positive patients with duodenal (n = 20) or gastric ulcer (n = 6), were treated with a three-day course of octreotide 0.3 mg/day subcutaneously, amoxicillin plus metronidazole 2 g/day orally and colloid bismuth subcitrate 480 mg/day. CLO-test, culture and crush tissue smears were performed on admission to the study, at 4 and 8 weeks post treatment. The effect of octreotide on intragastric pH (n = 10) was also investigated. RESULTS:
Octreotide significantly increased the mean 24-hour intragastric pH > 3 over 68.9% of the time (37.1%-99.5%). There were no treatment side effects. Ulcer pain was abolished at between 2-12 days. By intention-to-treat 24/26(92.3%, 95% CI 82%-100%) ulcers had healed at 4 weeks. H. pylori eradication rate at 8 weeks was 88.5% (23/26) (95% CI 76%-100%). CONCLUSIONS:
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Authors | S D Ladas, H Malamou-Lada, G Economou, P S Tassios, S A Raptis |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
1998 May-Jun
Vol. 45
Issue 21
Pg. 761-4
ISSN: 0172-6390 [Print] Greece |
PMID | 9684129
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adult
- Drug Administration Schedule
- Female
- Helicobacter Infections
(drug therapy)
- Helicobacter pylori
(isolation & purification)
- Humans
- Hydrogen-Ion Concentration
(drug effects)
- Male
- Middle Aged
- Octreotide
(administration & dosage, therapeutic use)
- Peptic Ulcer
(drug therapy)
- Pilot Projects
- Prospective Studies
- Treatment Outcome
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