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[Striato-nigral degeneration. A propos of 2 anatomo-clinical cases].

Abstract
Two sporadic cases of striato-nigral degeneration were characterized by the onset at the age of 61 of an akinetic-hypertonic syndrome and of a minimal or absent rest tremor, with a pyramidal syndrome, sphincter disorders, dysphonia, difficulty in swallowing and an unfavorable development in the space of two or three years not affected by L-Dopa. In one case, total insomnia was demonstrated by means of 3 polygraphic recordings during the night, two of them consecutive, and aprobenecide test showed a definite fall in H.V.A. and 5 H.I.A.A. in the lumbar cerebrospinal fluid. Anatomical verification showed, in one case, isolated putamino-nigral degeneration, and in the other associated with lesions of the olivo-cerebellopontine system. Much of the excess pigmentation found only in the putamen was melanotic in character and resulted perhaps from the striato-nigral degeneration, making it possible to classify this more accurately among the other multisystem degenerations, especially olivo-ponto-cerebellar atrophy and Shy-Drager syndrome
AuthorsD Michel, M Tommasi, B Laurent, M Trillet, B Schott
JournalRevue neurologique (Rev Neurol (Paris)) Vol. 132 Issue 1 Pg. 3-22 (Jan 1976) ISSN: 0035-3787 [Print] France
Vernacular TitleDégénérescence striato-nigrique. A propos de deux observations anatomo-cliniques
PMID968312 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Hydroxyindoleacetic Acid
  • Homovanillic Acid
Topics
  • Brain Diseases (cerebrospinal fluid, pathology, physiopathology)
  • Corpus Striatum
  • Female
  • Homovanillic Acid (cerebrospinal fluid)
  • Humans
  • Hydroxyindoleacetic Acid (cerebrospinal fluid)
  • Male
  • Middle Aged
  • Parkinson Disease (pathology, physiopathology)
  • Putamen (pathology)
  • Substantia Nigra (pathology)
  • Syndrome

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