Abstract |
Two sporadic cases of striato-nigral degeneration were characterized by the onset at the age of 61 of an akinetic-hypertonic syndrome and of a minimal or absent rest tremor, with a pyramidal syndrome, sphincter disorders, dysphonia, difficulty in swallowing and an unfavorable development in the space of two or three years not affected by L-Dopa. In one case, total insomnia was demonstrated by means of 3 polygraphic recordings during the night, two of them consecutive, and aprobenecide test showed a definite fall in H.V.A. and 5 H.I.A.A. in the lumbar cerebrospinal fluid. Anatomical verification showed, in one case, isolated putamino-nigral degeneration, and in the other associated with lesions of the olivo-cerebellopontine system. Much of the excess pigmentation found only in the putamen was melanotic in character and resulted perhaps from the striato-nigral degeneration, making it possible to classify this more accurately among the other multisystem degenerations, especially olivo-ponto-cerebellar atrophy and Shy-Drager syndrome
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Authors | D Michel, M Tommasi, B Laurent, M Trillet, B Schott |
Journal | Revue neurologique
(Rev Neurol (Paris))
Vol. 132
Issue 1
Pg. 3-22
(Jan 1976)
ISSN: 0035-3787 [Print] France |
Vernacular Title | Dégénérescence striato-nigrique. A propos de deux observations anatomo-cliniques |
PMID | 968312
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Hydroxyindoleacetic Acid
- Homovanillic Acid
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Topics |
- Brain Diseases
(cerebrospinal fluid, pathology, physiopathology)
- Corpus Striatum
- Female
- Homovanillic Acid
(cerebrospinal fluid)
- Humans
- Hydroxyindoleacetic Acid
(cerebrospinal fluid)
- Male
- Middle Aged
- Parkinson Disease
(pathology, physiopathology)
- Putamen
(pathology)
- Substantia Nigra
(pathology)
- Syndrome
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