Matrix metalloproteinases: the clue to intervertebral disc degeneration?

Abstract

STUDY DESIGN:

A review of the current literature on the role of matrix metalloproteinases in intervertebral disc degeneration.

OBJECTIVE:

To detail the characteristics of matrix metalloproteinases (classification, structure, substrate specificity and regulation) and to report previous studies of intervertebral discs.

SUMMARY OF BACKGROUND DATA:

Degeneration of the intervertebral disc, a probable prerequisite to disc herniation, is a complex phenomenon, and its physiopathologic course remains unclear. Matrix metalloproteinases probably play an important role but have received sparse attention in the literature.

METHODS:

A systematic review of studies reporting a role of matrix metalloproteinases in intervertebral disc degeneration.

RESULTS:

In several studies, investigators have reported the presence of proteolytic enzymes from disc culture systems and disc tissue extracts in degenerated human intervertebral discs, especially collagenase-1 (MMP-1) and stromelysin-1 (MMP-3). The matrix metalloproteinases are regulated by specific inhibitors (tissue inhibitors of metalloproteinases, or TIMPS), cytokines (interleukin-1), and growth factors.

CONCLUSIONS:

This field of application is of particular interest because conventional treatments are disappointing in chronic low back pain. Clinical trials with specific inhibitors of metalloproteinases are beginning in osteoarthritis.

• Authors: P Goupille, M I Jayson, J P Valat, A J Freemont
• Journal: Spine (Spine (Phila Pa 1976)) Vol. 23 Issue 14 Pg. 1612-26 (Jul 15 1998) ISSN: 0362-2436 [Print] United States
• PMID: 9682320 (Publication Type: Journal Article, Review, Systematic Review)

Chemical References

• Metalloendopeptidases

Topics

• Extracellular Matrix (enzymology)
• Humans
• Intervertebral Disc (enzymology, pathology)
• Intervertebral Disc Displacement (enzymology, etiology)
• Metalloendopeptidases (antagonists & inhibitors, chemistry, metabolism)