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Estrogen and progesterone receptors in the peripheral giant cell granulomas of the oral cavity.

Abstract
Peripheral giant cell granulomas are common proliferative lesions of the oral cavity with a predilection for females. In this study, the presence of estrogen and progesterone receptors in 26 peripheral giant cell granuloma cases were studied utilizing the immunoperoxidase technique. In fourteen cases, estrogen receptor positivity was found in stromal cells. In ten of these, osteoclast-type giant cells also exhibited estrogen receptor immunostaining. Progesterone receptor expression was not detected. It was concluded that the cells forming peripheral giant cell granuloma are potential targets for estrogens and that these lesions might be conditioned by sex hormones.
AuthorsM Günhan, O Günhan, B Celasun, M Mutlu, H Bostanci
JournalJournal of oral science (J Oral Sci) Vol. 40 Issue 2 Pg. 57-60 (Jun 1998) ISSN: 1343-4934 [Print] Japan
PMID9680761 (Publication Type: Journal Article)
Chemical References
  • Gonadal Steroid Hormones
  • Receptors, Estrogen
  • Receptors, Progesterone
Topics
  • Adolescent
  • Adult
  • Aged
  • Cell Nucleus (ultrastructure)
  • Child
  • Cytoplasm (ultrastructure)
  • Epithelium (pathology)
  • Female
  • Giant Cells (pathology)
  • Gonadal Steroid Hormones (therapeutic use)
  • Granuloma, Giant Cell (pathology)
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Mouth Diseases (pathology)
  • Mouth Mucosa (pathology)
  • Osteoclasts (pathology)
  • Receptors, Estrogen (analysis)
  • Receptors, Progesterone (analysis)
  • Sex Factors
  • Stromal Cells (pathology)

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