Abstract |
The inhibition of both phases of the formalin response by intrathecal (IT) clonidine and baclofen, given alone or in combination at a fixed dose ratio, was studied. Both drugs, at doses not affecting motor performance, produced a dose-dependent inhibition of phase 2 of the formalin test. The potency of baclofen and clonidine, defined by their ID50's for phase 2 of the formalin test, was 0.56 and 3.4 nmol, respectively. The combination ID50 of baclofen and clonidine, with the equieffective dose ratio of 1:6, was found to be statistically lower than the theoretical additive ID50. These data suggest that co-administration of alpha2-adrenoceptor or GABA(B) receptor agonists may prove therapeutically useful in treating chronic pain.
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Authors | K Przesmycki, J A Dzieciuch, S J Czuczwar, Z Kleinrok |
Journal | Neuropharmacology
(Neuropharmacology)
Vol. 37
Issue 2
Pg. 207-14
( 1998)
ISSN: 0028-3908 [Print] England |
PMID | 9680245
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic alpha-Agonists
- Adrenergic alpha-Antagonists
- GABA Agonists
- Imidazoles
- atipamezole
- Formaldehyde
- Baclofen
- Clonidine
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Topics |
- Adrenergic alpha-Agonists
(pharmacology)
- Adrenergic alpha-Antagonists
(pharmacology)
- Animals
- Baclofen
(pharmacology)
- Clonidine
(pharmacology)
- Drug Interactions
- Formaldehyde
- GABA Agonists
(pharmacology)
- Imidazoles
(pharmacology)
- Injections, Spinal
- Male
- Motor Activity
(drug effects)
- Pain Threshold
(drug effects)
- Rats
- Rats, Wistar
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