Abstract | BACKGROUND: METHOD: Twelve patients who met DSM-IV diagnostic criteria for adult ADHD and cocaine dependence were entered into a 12-week trial of divided daily doses of sustained-release methylphenidate ranging from 40 to 80 mg. In addition to the pharmacotherapy, patients also received individual weekly relapse prevention therapy. Individuals were assessed weekly for ADHD symptoms; vital signs and urine toxicologies were obtained 3 times a week. RESULTS: Of the 12 patients entered, 10 completed at least 8 weeks of the study and 8 completed the entire study. Using both a semistructured clinical interview and a self-report assessment, patients reported reductions in attention difficulties, hyperactivity, and impulsivity. Self-reported cocaine use and craving decreased significantly. More importantly, cocaine use, confirmed by urine toxicologies, also decreased significantly. CONCLUSION:
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Authors | F R Levin, S M Evans, D M McDowell, H D Kleber |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 59
Issue 6
Pg. 300-5
(Jun 1998)
ISSN: 0160-6689 [Print] United States |
PMID | 9671342
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Delayed-Action Preparations
- Methylphenidate
- Cocaine
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Topics |
- Adult
- Ambulatory Care
- Attention Deficit Disorder with Hyperactivity
(drug therapy, epidemiology)
- Behavior Therapy
- Cocaine
(urine)
- Cocaine-Related Disorders
(drug therapy, epidemiology, prevention & control)
- Combined Modality Therapy
- Comorbidity
- Delayed-Action Preparations
- Drug Administration Schedule
- Female
- Humans
- Male
- Methylphenidate
(administration & dosage, therapeutic use)
- Personality Inventory
- Pilot Projects
- Psychiatric Status Rating Scales
- Secondary Prevention
- Substance Abuse Detection
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