Abstract | PURPOSE: METHODS: In this double blind randomized study, 120 female patients scheduled for laparoscopic procedures were studied. They were divided into six groups of 20 according to the non-depolarizing pretreatment used: NaCl 0.9% (control), 0.05 mg.kg-1 d-tubocurarine, 0.01 mg.kg-1 vecuronium, 0.05 mg.kg-1 atracurium, 0.02 mg.kg-1 mivacurium and 0.06 mg.kg-1 rocuronium. Four minutes after the pretreatment, 1.5 mg.kg-1 succinylcholine was injected. Side effects of the pretreatment, the presence and magnitude of fasciculations, the ease of tracheal intubation, myalgia 1, 24 and 48 hr after surgery were observed. A Puritan Bennett Datex 221 NMT Relaxograph monitor was used to evaluate the neuromuscular block. RESULTS: Muscle fasciculations were observed in 19 of the 20 patients in the control group and in 3 of the 20 patients in the rocuronium group, the best of the pretreatments in that aspect. Four patients in the mivacurium group were unable to sustain more than four seconds head-lift after pretreatment (P < 0.05). Tracheal intubation conditions were better and the onset of block was faster and longer after succinylcholine in the control group (P < 0.05). Myalgias were present in 71% of the patients 24 hr postoperatively and the frequency was not different among the groups. CONCLUSION:
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Authors | R Martin, J Carrier, M Pirlet, Y Claprood, J P Tétrault |
Journal | Canadian journal of anaesthesia = Journal canadien d'anesthesie
(Can J Anaesth)
Vol. 45
Issue 6
Pg. 521-5
(Jun 1998)
ISSN: 0832-610X [Print] United States |
PMID | 9669004
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Androstanols
- Isoquinolines
- Neuromuscular Depolarizing Agents
- Neuromuscular Nondepolarizing Agents
- Atracurium
- Mivacurium
- Vecuronium Bromide
- Succinylcholine
- Tubocurarine
- Rocuronium
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Topics |
- Adult
- Androstanols
(administration & dosage)
- Atracurium
(administration & dosage)
- Double-Blind Method
- Fasciculation
(prevention & control)
- Female
- Follow-Up Studies
- Humans
- Intubation, Intratracheal
- Isoquinolines
(administration & dosage)
- Laparoscopy
- Mivacurium
- Muscle, Skeletal
(drug effects)
- Neuromuscular Blockade
- Neuromuscular Depolarizing Agents
(adverse effects)
- Neuromuscular Nondepolarizing Agents
(administration & dosage)
- Pain
(prevention & control)
- Rocuronium
- Succinylcholine
(adverse effects)
- Time Factors
- Tubocurarine
(administration & dosage)
- Vecuronium Bromide
(administration & dosage)
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