Abstract |
The efficacy of an Indian preparation of immune serum globulins (ISG) was evaluated among pregnant women during an epidemic of hepatitis E in Karad, Western India from January to March 1993. Ten of 55 women receiving ISG developed immunoglobulin M ( IgM) antibodies to hepatitis E virus (anti-HEV) during the 1 month of follow-up compared with 18 out of 53 control subjects. Although the total number of recent HEV infections was significantly less in the ISG-treated group, no significant difference could be shown in the proportion of clinical hepatitis E cases because of the very small numbers of patients who developed clinical disease. The observed marginal beneficial effect of ISG might be the result of a low immunoglobulin G ( IgG) anti-HEV IgG titre (1:500) of the ISG preparation used. Preparation and testing of high-titred ISG should be a high priority for protecting pregnant women during epidemics of hepatitis E.
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Authors | V A Arankalle, M S Chadha, B M Dama, S A Tsarev, R H Purcell, K Banerjee |
Journal | Journal of viral hepatitis
(J Viral Hepat)
Vol. 5
Issue 3
Pg. 199-204
(May 1998)
ISSN: 1352-0504 [Print] England |
PMID | 9658374
(Publication Type: Journal Article)
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Chemical References |
- Hepatitis Antibodies
- Immune Sera
- Immunoglobulins
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Topics |
- Disease Outbreaks
- Female
- Hepatitis Antibodies
(immunology)
- Hepatitis E
(epidemiology, immunology, prevention & control)
- Hepatitis E virus
(genetics, immunology)
- Humans
- Immune Sera
(immunology)
- Immunoglobulins
(immunology)
- Pregnancy
- Pregnancy Complications, Infectious
(epidemiology, immunology, prevention & control)
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