Antitussive effect of moguisteine on allergic coughs in the guinea pig.

Abstract

The effect of moguisteine, a novel peripherally acting non-narcotic antitussive drug, on allergic coughs was examined in guinea pigs. Male Hartley guinea pigs were actively sensitized to ovalbumin. The number of coughs elicited over 5 min following a 2-min exposure to ovalbumin was counted. Exposure of sensitized guinea pigs to 0.5% ovalbumin aerosol induced 22.0 +/- 3.2 coughs/5 min. Moguisteine at doses of 30 and 56 mg/kg, p.o., dose-dependently and significantly suppressed the number of allergic coughs. Dihydrocodeine at doses of 30 and 56 mg/kg, p.o., dose-dependently but not significantly reduced the number of allergic coughs. These results suggest that moguisteine may be of a therapeutic benefit in reducing allergic coughs.

• Authors: J Kamei, K Morita, T Kashiwazaki, M Ohsawa
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 347 Issue 2-3 Pg. 253-5 (Apr 24 1998) ISSN: 0014-2999 [Print] Netherlands
• PMID: 9653890 (Publication Type: Journal Article)

Chemical References

• Analgesics, Opioid
• Antitussive Agents
• Thiazoles
• Thiazolidines
• moguisteine
• dihydrocodeine
• Codeine

Topics

• Analgesics, Opioid (therapeutic use)
• Animals
• Antitussive Agents (administration & dosage, therapeutic use)
• Codeine (analogs & derivatives, therapeutic use)
• Cough (drug therapy, physiopathology)
• Disease Models, Animal
• Guinea Pigs
• Hypersensitivity (drug therapy, physiopathology)
• Male
• Thiazoles (administration & dosage, therapeutic use)
• Thiazolidines