Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.

Abstract

OBJECTIVE:

To clarify the contribution of the Asp905Tyr polymorphism of the muscle-specific glycogen-targeting subunit of protein phosphatase 1 (PP1G) to insulin resistance and related diseases.

RESEARCH DESIGN AND METHODS:

We investigated the Asp905Tyr polymorphism of the PPP1R3 gene, which encodes the muscle-specific glycogen-targeting subunit of PP1G, in 259 Japanese patients with NIDDM and 194 healthy control subjects.

RESULTS:

No significant difference was found in the genotype distribution between NIDDM patients (N = 259; Asp/Asp = 0.10, Asp/Tyr = 0.44, Tyr/Try = 0.46) and healthy control subjects (n = 194; Asp/Asp = 0.13, Asp/Tyr = 0.37, Tyr/Tyr = 0.50) or between patient groups subdivided by the mode of treatment: NIDDM patients with insulin therapy (Asp/Asp = 0.14, Asp/Tyr = 0.46, Tyr/Tyr = 0.40) and those without insulin therapy (Asp/Asp = 0.07, Asp/Tyr = 0.43, Tyr/Tyr = 0.50). However, NIDDM patients with the Tyr allele, which was previously reported to be associated with insulin resistance, tended to have lower BMIs than those without this allele (Asp/Asp: 24.5 +/- 1.1 kg/m2, Asp/Tyr: 22.6 +/- 0.4 kg/m2, Tyr/Tyr: 22.8 + 0.3 kg/m2, P = 0.06 by analysis of variance).

CONCLUSIONS:

These data suggest that the Asp905Tyr polymorphism of the PPP1R3 gene is not associated with NIDDM or high BMI, both of which are known to be insulin-resistant states, in the Japanese population.

• Authors: G Q Shen, H Ikegami, Y Kawaguchi, T Fujisawa, Y Hamada, H Ueda, M Shintani, K Nojima, Y Kawabata, K Yamada, N Babaya, T Ogihara
• Journal: Diabetes care (Diabetes Care) Vol. 21 Issue 7 Pg. 1086-9 (Jul 1998) ISSN: 0149-5992 [Print] United States
• PMID: 9653600 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hypoglycemic Agents
• Insulin
• Aspartic Acid
• Tyrosine
• Glycogen
• Phosphoprotein Phosphatases
• Protein Phosphatase 1

Topics

• Adult
• Aged
• Alleles
• Amino Acid Substitution (genetics)
• Aspartic Acid (genetics)
• Body Mass Index
• Data Interpretation, Statistical
• Diabetes Mellitus, Type 2 (drug therapy, enzymology, genetics)
• Female
• Gene Frequency
• Genes (genetics)
• Genotype
• Glycogen (metabolism)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin (therapeutic use)
• Male
• Middle Aged
• Muscle, Skeletal (enzymology)
• Phosphoprotein Phosphatases (genetics)
• Polymorphism, Genetic
• Protein Phosphatase 1
• Tyrosine (genetics)