[The effect of pharmacologic prophylaxis with Panpal on acetylcholinesterase activity in the diaphragm and various parts of the brain in rats during treated and untreated Soman poisoning].

Abstract

BACKGROUND:

The pharmacological prophylaxis protecting the organism against organophosphorus compounds could increase the effect of antidotal treatment of poisoning with organophosphates.

METHODS AND RESULTS:

The influence of the pharmacological prophylaxis with Panpal (pyridostigmine in combination with benaetyzine and trihexyphenidyle) on acetylcholinesterase activity in diaphragm and various parts of brain at 1 and 3 h following non-treated and treated (the oxime HI-6 in combination with atropine) soman poisoning was tested on male rats. While Panpal did not significantly influence the acetylcholinesterase activity in brain following non-treated as well as treated soman poisoning. Panpal increased so many-induced acetylcholinesterase inhibition following non-treated poisoning and decreased the reactivating effect of the oxime HI-6 following treated soman poisoning in diaphragm.

CONCLUSIONS:

Our data confirm the importance of the combination of reversible acetylcholinesterase inhibitor pyridostigmine with anticholinergic drugs in the pharmacological prophylaxis of soman poisoning because of the elimination of consequences of pyridostigmine-induced increasing in acetylcholinesterase inhibition in the peripheral compartment.

• Authors: J Kassa
• Journal: Casopis lekaru ceskych (Cas Lek Cesk) Vol. 137 Issue 10 Pg. 299-302 (May 18 1998) ISSN: 0008-7335 [Print] Czech Republic
• Vernacular Title: Vliv farmakologické profylaxe Panpalem na aktivitu acetylcholinesterázy v bránici a různých cástech mozku potkana v průbĕhu nelécené a lécené intoxikace somanem.
• PMID: 9650360 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidotes
• Chemical Warfare Agents
• Cholinesterase Inhibitors
• Cholinesterase Reactivators
• Drug Combinations
• Oximes
• Pyridinium Compounds
• Benactyzine
• Trihexyphenidyl
• Atropine
• Soman
• Acetylcholinesterase
• asoxime chloride
• Pyridostigmine Bromide

Topics

• Acetylcholinesterase (metabolism)
• Animals
• Antidotes (therapeutic use)
• Atropine (therapeutic use)
• Benactyzine (administration & dosage, pharmacology)
• Brain (enzymology)
• Chemical Warfare Agents (poisoning)
• Cholinesterase Inhibitors (poisoning)
• Cholinesterase Reactivators (therapeutic use)
• Diaphragm (enzymology)
• Drug Combinations
• Male
• Oximes
• Poisoning (drug therapy, prevention & control)
• Pyridinium Compounds (therapeutic use)
• Pyridostigmine Bromide (administration & dosage, pharmacology)
• Rats
• Rats, Wistar
• Soman (poisoning)
• Trihexyphenidyl (administration & dosage, pharmacology)