Abstract | BACKGROUND: METHODS AND RESULTS: Plasma levels of TNF alpha, its soluble receptor p75 (sTNF-RII), IL-6 and soluble IL-6 receptor (sIL-6R) were measured using ELISA in 17 pts with ANCA-positive renal vasculitis (12 active- ANCA- A, 7 in remission ANCA-R), 9 pts with active lupus nephritis (LN) and 5 healthy subjects. Pts with LN had in comparison with controls increased plasma levels of TNF alpha, sTNF-RII, IL-6 and sIL-6R. Pts with ANCA-A had also in comparison with controls increased plasma levels of TNF alpha, sTNF-RII and sIL-6R, but plasma levels of IL-6 were not significantly increased dut to great standard deviation. Pts with ANCA-R had in comparison with controls increased plasma levels of sTNF-RII, but plasma levels of TNF alpha were in ANCA-R significantly lower than in ANCA-A. While the ratio TNF alpha/sTNF-RII was significantly lower in all groups of pts than in controls, the ratio IL-6R/sIL-6R was in comparison with controls significantly increased only in LN. CONCLUSIONS: While increased plasma levels of TNF alpha may be nonspecific marker of the activity of ANCA-positive renal vasculitis and LN, plasma levels of sTNF-RII are increased also in pts with ANCA-positive renal vasculitis in remission. Increased plasma levels of sTNF-RII may interfere with systemic effects of TNF alpha, but may also prolong the lifetime of its active form. Plasma levels of sIL-6R are increased both in ANCA-A and in LN, but their increase is, however, much less pronounced than that of sTNF-RII and cannot effectively block systemic effects of IL-6.
|
Authors | V Tesar, M Jirsa Jr, Z Masek, J Bartůnková, A Stejskalová, C Dostál, J Zabka, V Chábová, R Rysavá |
Journal | Casopis lekaru ceskych
(Cas Lek Cesk)
Vol. 137
Issue 9
Pg. 271-5
(May 04 1998)
ISSN: 0008-7335 [Print] Czech Republic |
Vernacular Title | Solubilní receptory pro cytokiny u renální vaskulitidy a lupoidní nefritidy. |
PMID | 9650355
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
- Interleukin-6
- Receptors, Cytokine
- Receptors, Interleukin-6
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha
|
Topics |
- Adult
- Antibodies, Antineutrophil Cytoplasmic
(analysis)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Interleukin-6
(blood)
- Kidney Diseases
(blood, immunology)
- Lupus Nephritis
(blood)
- Male
- Middle Aged
- Receptors, Cytokine
(blood)
- Receptors, Interleukin-6
(blood)
- Receptors, Tumor Necrosis Factor
(blood)
- Solubility
- Tumor Necrosis Factor-alpha
(analysis)
- Vasculitis
(blood, immunology)
|