Immunolocalization of apolipoprotein D, androgen receptor and prostate specific antigen in early stage prostate cancers.

Abstract

PURPOSE:

To determine the cellular distribution and levels of immunohistochemical staining for apolipoprotein D (Apo-D), prostate specific antigen (PSA) and androgen receptor (AR) in early stage prostate cancers.

MATERIALS AND METHODS:

Cellular distribution of Apo-D, PSA and AR in 30 stage A/B prostate cancers and in non-malignant glandular tissue contained in the same sections was detected immunohistochemically, and staining was evaluated by computerized video image analysis.

RESULTS:

Staining for Apo-D (percentage positive cellular area) was significantly increased in tumor cells of early stage prostate cancers compared with non-malignant glandular tissue. PSA and AR were present at high levels in both early stage prostate tumors and non-malignant prostate.

CONCLUSIONS:

Malignant transformation in the prostate is associated with increased cellular levels of Apo-D.

• Authors: S X Zhang, J M Bentel, C Ricciardelli, D J Horsfall, D E Haagensen, V R Marshall, W D Tilley
• Journal: The Journal of urology (J Urol) Vol. 159 Issue 2 Pg. 548-54 (Feb 1998) ISSN: 0022-5347 [Print] United States
• PMID: 9649289 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Apolipoproteins
• Apolipoproteins D
• Receptors, Androgen
• Prostate-Specific Antigen

Topics

• Apolipoproteins (analysis)
• Apolipoproteins D
• Humans
• Immunohistochemistry
• Male
• Neoplasm Staging
• Prostate-Specific Antigen (analysis)
• Prostatic Neoplasms (chemistry, pathology)
• Receptors, Androgen (analysis)