Abstract | PURPOSE: MATERIALS AND METHODS: A total of 231 patients with a history of transitional cell carcinoma provided 288 voided urine samples before cystoscopic examination at 1 of 3 institutions (53 patients were reevaluated at least once). Urine samples were assayed for NMP22 using the NMP22 Test Kit. Select patients underwent biopsy with appropriate additional therapy. Voided urinary cytology was obtained in 200 cases. End points for determination of the absence and presence of tumor were negative cystoscopy and positive biopsy, respectively. A receiver operating characteristics curve was constructed to determine the optimal NMP22 threshold for detection of transitional cell carcinoma. For positive biopsies NMP22 values were also correlated with tumor stage and grade. Comparison to cytology was limited to patients with complete data. RESULTS: There were 208 negative cystoscopies (158 with cytology) and 66 positive cystoscopies with biopsy (42 with cytology). Of the cases 14 were eliminated from statistical analysis due to incomplete data. Receiver operating characteristics curve interpretation determined that 6.4 units per ml. was an optimal reference value for detection of transitional cell carcinoma in this patient group. Sensitivity and specificity for all pathological groupings was 68 and 80%, respectively. When compared to cytology the sensitivities of NMP22 and cytology were 67 versus 31 or 40% (depending on the definition of positive cytology). CONCLUSIONS:
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Authors | D S Stampfer, G A Carpinito, J Rodriguez-Villanueva, L W Willsey, C P Dinney, H B Grossman, H A Fritsche, W S McDougal |
Journal | The Journal of urology
(J Urol)
Vol. 159
Issue 2
Pg. 394-8
(Feb 1998)
ISSN: 0022-5347 [Print] United States |
PMID | 9649246
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Nuclear Proteins
- nuclear matrix protein 22
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Topics |
- Aged
- Biomarkers, Tumor
(urine)
- Carcinoma, Transitional Cell
(urine)
- Evaluation Studies as Topic
- Female
- Humans
- Male
- Nuclear Proteins
(urine)
- Sensitivity and Specificity
- Urinary Bladder Neoplasms
(urine)
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