Prognostic significance of DNA ploidy and S-phase fraction in malignant serous cystadenocarcinoma of the ovary.

Abstract

OBJECTIVE:

To determine the prognostic value of DNA ploidy and S-phase fraction in malignant serous cystadenocarcinoma of the ovary.

STUDY DESIGN:

Flow cytometric analysis of nuclear DNA content was performed on paraffin-embedded tissues of 31 serous cystadenocarcinomas of the ovary. DNA ploidy, DNA index and S-phase fraction were determined without knowing the final outcome in the patients.

RESULTS:

Histograms in 14 (46%) cases were aneuploid, whereas 17 (54%) were diploid. Aneuploidy was more frequent at the advanced stages of the disease as well as in the poorly differentiated histologic types. However, ploidy had a prognostic influence: both the disease-free survival and overall survival were better in diploid than aneuploid tumors at early and advanced stages. S-phase fraction (SPF) could be correctly assessed in 19 cases (62%) and was > 15% in 21% (4 cases). The survival of those patients, however, was not significantly different from that of those with SPF < 15%.

CONCLUSION:

If used as an adjunct, DNA ploidy is of value in predicting tumor behavior, response to chemotherapy and disease recurrence.

• Authors: N Bakshi, A Rajwanshi, F Patel, N K Ganguly
• Journal: Analytical and quantitative cytology and histology (Anal Quant Cytol Histol) Vol. 20 Issue 3 Pg. 215-20 (Jun 1998) United States
• PMID: 9642449 (Publication Type: Journal Article)

Chemical References

• DNA, Neoplasm

Topics

• Adult
• Cystadenocarcinoma, Serous (diagnosis, genetics, pathology)
• DNA, Neoplasm
• Female
• Humans
• Middle Aged
• Ovarian Neoplasms (diagnosis, genetics, pathology)
• Ploidies
• Prognosis
• S Phase (genetics)