Abstract | BACKGROUND: OBJECTIVE: We studied two patients who experienced respiratory and food allergic symptoms upon exposure to egg or avian antigens through the inhalative or digestive routes. Clinical and immunological studies were carried out in order to identify individual allergens from these sources that could be responsible for crossreactivity reactions. RESULTS: Patient 1 showed IgE sensitization to egg yolk livetins, feathers, and chicken serum. Specific bronchial challenge with chicken albumin and livetin extracts elicited a positive early asthmatic response and an increase in serum eosinophil cationic protein. Immunoblot and CAP-inhibition studies in this patient supported that chicken albumin ( alpha-livetin) was the crossreactive antigen present in egg yolk and chicken serum and feathers. Patient 2 showed sensitization to egg white, ovomucoid and lysozyme. However, SDS-PAGE and immunoblot studies demonstrated contaminating lysozyme in the ovomucoid extract and identified lysozyme as the main allergen causing egg sensitization in this patient. Conjunctival challenge test confirmed allergy to lysozyme. CONCLUSION:
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Authors | S Quirce, M L Díez-Gómez, P Eiras, M Cuevas, G Baz, E Losada |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 28
Issue 4
Pg. 478-85
(Apr 1998)
ISSN: 0954-7894 [Print] England |
PMID | 9641575
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Allergens
- Antibodies
- Egg Proteins
- Sodium Dodecyl Sulfate
- Immunoglobulin E
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Topics |
- Adult
- Allergens
(adverse effects, metabolism)
- Antibodies
(metabolism)
- Asthma
(chemically induced)
- Bronchial Provocation Tests
- Conjunctiva
(drug effects)
- Conjunctivitis, Allergic
(chemically induced, etiology)
- Egg Proteins
(adverse effects)
- Electrophoresis, Polyacrylamide Gel
- Female
- Food Hypersensitivity
(etiology)
- Histamine Release
- Humans
- Immunoblotting
- Immunoglobulin E
(blood)
- Respiratory Hypersensitivity
(chemically induced)
- Rhinitis, Allergic, Seasonal
(chemically induced)
- Skin Tests
- Sodium Dodecyl Sulfate
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