Abstract | OBJECTIVE: To describe the pharmacology, pharmacokinetics, and clinical efficacy of mibefradil compared with other agents used for hypertension and angina. DATA SOURCES: A MEDLINE search was performed for the period of January 1980 through September 1997 using the key terms mibefradil or Ro 40-5967. All articles written in English were considered for review. STUDY SELECTION AND DATA EXTRACTION: All clinical studies involving mibefradil were evaluated. Preclinical data were included if these data were not adequately represented in clinical (human) studies. DATA SYNTHESIS: CONCLUSIONS: Clinical studies have found that the antihypertensive effects of mibefradil are comparable with those of nifedipine, verapamil, and amlodipine, and more effective than those of diltiazem. These effects result from peripheral vasodilation and a slight reduction in heart rate. Selective vasodilation of the coronary vasculature makes it an effective antianginal agent when used alone or added to beta-blocker therapy. Mibefradil demonstrates no significant effects on cardiac contractility, and no adrenergic stimulation resulting in reflex tachycardia. Therefore, it may have some advantages over currently available CCAs, especially in patients with congestive heart failure, although such advantages are unproven in published clinical trials. Ongoing clinical studies, including the Mortality Assessment in Congestive Heart Failure Trial (MACH-1) currently in progress, are needed to clarify mibefradil's place in cardiovascular therapy.
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Authors | S J Billups, B L Carter |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 32
Issue 6
Pg. 659-71
(Jun 1998)
ISSN: 1060-0280 [Print] United States |
PMID | 9640486
(Publication Type: Journal Article, Review)
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Chemical References |
- Benzimidazoles
- Calcium Channel Blockers
- Tetrahydronaphthalenes
- Mibefradil
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Topics |
- Aged
- Angina Pectoris
(drug therapy)
- Benzimidazoles
(adverse effects, pharmacokinetics, pharmacology, therapeutic use)
- Calcium Channel Blockers
(adverse effects, pharmacokinetics, pharmacology, therapeutic use)
- Clinical Trials as Topic
- Drug Interactions
- Drug Therapy, Combination
- Female
- Humans
- Hypertension
(drug therapy)
- Male
- Mibefradil
- Tetrahydronaphthalenes
(adverse effects, pharmacokinetics, pharmacology, therapeutic use)
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