Open field tests were made on 489 white male rats to distinguish subgroups by baseline higher nervous activity (HNA) to study the effects of
cerebrolysin (EBEVE, Austria) on relationships between neuronal activity and cerebral blood supply in normal cerebral circulation (CC) and in acute
brain ischemia. Local CC and EEG were measured by
laser doppler
flowmeter and read from the same point gauge. CC/EEG index was calculated.
Cerebrolysin was injected i.p. in a dose 0.3 ml/100 g body mass.
Brain ischemia was provoked by occlusion of the common carotid arteries. Neurological symptoms were estimated according to the McGrow scale. Also, 24-h lethality was registered. It was confirmed that
cerebrolysin, as an active
nootrop, enhances EEG. This effect takes place both in intact and
brain ischemia rats. It was also found that
cerebrolysin has different effectiveness dependent on the animal's behavior in the open field test, that blood supply to the brain does not increase in
cerebrolysin-activated HNA. In stable circulation, this was compensated due to cerebral metabolic reserve, but in intensive EEG activation, recorded by CC/EEG index,
cerebrolysin reduces cerebral blood supply aggravating acute
brain ischemia.