Epidermoid cyst of the spleen with CA19-9 or carcinoembryonic antigen productions: report of three cases.

Abstract

True splenic cyst is a relatively rare disease, and the majority of the cases are classified as epidermoid cysts. Three cases of epidermoid cysts in the spleen or accessory spleen were studied using an immunohistochemical technique and staining for mucin. In case 1, serum carcinoembryonic antigen (CEA) and CA19-9, and in cases 2 and 3, serum CA19-9, before surgery were markedly elevated, and these levels decreased postoperatively. This strongly indicates the relationship between the increase of tumor marker levels and the presence of the epidermoid cyst. In addition, stratified squamous epithelium in the resected tissues of cases 1 and 2 was positive for anti-CEA antibody and anti-CA19-9 antibody, and that of case 3 was positive for anti-CA19-9 antibody. This strongly supports CEA or CA19-9 production in the squamous epithelium.

• Authors: K Higaki, A Jimi, J Watanabe, A Kusaba, M Kojiro
• Journal: The American journal of surgical pathology (Am J Surg Pathol) Vol. 22 Issue 6 Pg. 704-8 (Jun 1998) ISSN: 0147-5185 [Print] United States
• PMID: 9630177 (Publication Type: Case Reports, Journal Article)

Chemical References

• CA-19-9 Antigen
• Carcinoembryonic Antigen

Topics

• Adult
• Angiography
• CA-19-9 Antigen (metabolism)
• Carcinoembryonic Antigen (metabolism)
• Epidermal Cyst (diagnostic imaging, metabolism, pathology)
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Splenic Diseases (diagnostic imaging, metabolism, pathology)
• Tomography, X-Ray Computed