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[Drug treatment of Crohn's disease].

Abstract
The medical management of Crohn's disease has changed in recent years, but the mainstay of treatment is still prednisone. A substantial fraction of steroid-treated patients are refractory to therapy and addition of azathioprine or methotrexate has a corticosteroid-sparing effect and increases duration of remission. Controlled ileal release budesonide (9 mg daily) induces clinical remission in 60-70% of patients with Crohn's ileitis or right-sided colitis, and continued budesonide treatment has a finite effect on the duration of remission. The efficacy of mesalazine in active Crohn's disease is limited and high doses are required (4000 mg/day). The role of mesalazine in Crohn's disease in remission is disputed, and there is no evidence of a corticosteroid-sparing effect.
AuthorsS J van Deventer, G N Tytgat
JournalNederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 142 Issue 21 Pg. 1191-5 (May 23 1998) ISSN: 0028-2162 [Print] Netherlands
Vernacular TitleMedicamenteuze behandeling van de ziekte van Crohn.
PMID9627451 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents, Non-Steroidal
  • Immunosuppressive Agents
  • Mesalamine
  • Budesonide
  • Cyclosporine
  • Azathioprine
  • Prednisone
  • Methotrexate
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
  • Azathioprine (administration & dosage)
  • Budesonide (administration & dosage)
  • Clinical Protocols (standards)
  • Crohn Disease (drug therapy)
  • Cyclosporine (administration & dosage)
  • Drug Therapy, Combination
  • Humans
  • Immunosuppressive Agents (administration & dosage)
  • Mesalamine (administration & dosage)
  • Methotrexate (administration & dosage)
  • Prednisone (administration & dosage)
  • Remission Induction
  • Treatment Outcome

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