Abstract | OBJECTIVE: Previous research has demonstrated that a theoretical model including measures of life stressors, social support, and coping style significantly predicts psychological distress. This study tested plasma pyridoxine ( vitamin B6) deficiency status as a predictor of overall psychological distress and specific mood states in this model, controlling for HIV-1 serostatus. METHOD: Subjects included HIV-1+ (N = 76) and HIV-1- (N = 58) recently bereaved homosexual men. At baseline, subjects completed a battery of psychosocial questionnaires, together with a physical examination and venipuncture. The Profile of Mood States (POMS) provided measures of overall psychological distress as well as specific mood states. Pyridoxine deficiency status (a categorical measure of deficient vs. adequate status) was determined with a bioassay of erythrocyte aspartate aminotransferase activity. RESULTS:
Pyridoxine deficiency was a significant predictor of increased overall psychological distress in this model, controlling for life stressors, social support, coping style, and HIV-1 serostatus. In post hoc analyses of specific mood state effects, pyridoxine deficiency status was significantly associated with increases in depressed, fatigued, and confused mood levels, but not with those of anxiety, anger, or vigor. DISCUSSION:
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Authors | T Baldewicz, K Goodkin, D J Feaster, N T Blaney, M Kumar, A Kumar, G Shor-Posner, M Baum |
Journal | Psychosomatic medicine
(Psychosom Med)
1998 May-Jun
Vol. 60
Issue 3
Pg. 297-308
ISSN: 0033-3174 [Print] United States |
PMID | 9625217
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adaptation, Psychological
(physiology)
- Adult
- Affect
(physiology)
- Bereavement
- Depression
(blood, psychology)
- HIV Seropositivity
(blood, psychology)
- HIV-1
- Homosexuality, Male
(psychology)
- Humans
- Life Change Events
- Male
- Middle Aged
- Pyridoxine
(blood)
- Stress, Psychological
(blood, complications)
- Vitamin B 6 Deficiency
(blood, psychology)
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