Abstract | BACKGROUND: METHODS: Conjunctival biopsy specimens obtained from patients with subacute (n = 8) or chronic conjunctival disease (n = 13) were analysed histologically and immunohistochemically using antibodies directed against EG1 (stored and secreted ECP), EG2 (secreted ECP), MBP, CD45 (common leucocyte antigen), CD3 (pan T cell marker), and HLA-DR ( class II antigen). RESULTS: Subepithelial mononuclear cells, mast cells, and neutrophils were detected in all specimens. The number of mononuclear cells, neutrophils, CD45+ cells, CD3+ cells, and the HLA-DR expression were significantly higher in the subacute than in the chronic disease group. Some eosinophils were found in specimens from five of eight patients with subacute OCP, but in none of the patients with chronic disease. The eosinophil granule proteins (ECP and MBP) were found in the epithelium and substantia propria in patients with subacute conjunctivitis. CONCLUSIONS:
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Authors | A Heiligenhaus, J Schaller, S Mauss, S Engelbrecht, J E Dutt, C S Foster, K P Steuhl |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 82
Issue 3
Pg. 312-7
(Mar 1998)
ISSN: 0007-1161 [Print] England |
PMID | 9602632
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers
- Blood Proteins
- CD3 Complex
- Eosinophil Granule Proteins
- HLA-DR Antigens
- Ribonucleases
- Leukocyte Common Antigens
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
- Biopsy
- Blood Proteins
(metabolism)
- CD3 Complex
(analysis)
- Conjunctival Diseases
(etiology, metabolism)
- Eosinophil Granule Proteins
- Female
- HLA-DR Antigens
(analysis)
- Humans
- Immunohistochemistry
- Leukocyte Common Antigens
(analysis)
- Male
- Middle Aged
- Pemphigoid, Benign Mucous Membrane
(complications, genetics, metabolism)
- Ribonucleases
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