The anticonvulsant zonisamide scavenges free radicals.

Abstract

Zonisamide (ZNS) is effective in animal models of epilepsy and epileptic patients. The free radical scavenging activities of ZNS were analyzed by using electron spin resonance. ZNS, in the mmolar range, scavenged hydroxyl and nitric oxide radicals in a dose-dependent manner. This suggests that the mechanism of antiepileptic effect of ZNS may involve protection of neurons from free radical damage and stabilization of neuronal membranes.

• Authors: A Mori, Y Noda, L Packer
• Journal: Epilepsy research (Epilepsy Res) Vol. 30 Issue 2 Pg. 153-8 (Apr 1998) ISSN: 0920-1211 [Print] Netherlands
• PMID: 9600546 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Free Radical Scavengers
• Free Radicals
• Indicators and Reagents
• Isoxazoles
• Superoxides
• Nitric Oxide
• Hydroxyl Radical
• Zonisamide

Topics

• Anticonvulsants (chemistry)
• Electron Spin Resonance Spectroscopy
• Free Radical Scavengers (chemistry)
• Free Radicals (chemistry)
• Hydroxyl Radical (chemistry)
• Indicators and Reagents
• Isoxazoles (chemistry)
• Nitric Oxide (chemistry)
• Reference Standards
• Superoxides (chemistry)
• Zonisamide