Gastroesophageal reflux association with laryngomalacia: a prospective study.

Abstract

OBJECTIVE:

To identify the incidence and clinical role of gastroesophageal reflux (GER) in patients with laryngomalacia.

DESIGN:

Prospective evaluation of consecutive infants with a new diagnosis of laryngomalacia with an initial questionnaire, a barium esophagram or 24 h pH probe and record of their subsequent clinical course.

SETTING:

A large, tertiary pediatric referral center and its associated outpatient clinic.

PATIENTS:

New diagnosis of laryngomalacia in 33 consecutive infants were evaluated by questionnaire and 27 of these were evaluated for GER.

RESULTS:

GER was observed in 64% of patients and was significantly associated with severe symptoms and complicated clinical course (P = 0.0163). The presence of smokers in the infant's household negatively impacted his or her clinical course and symptomatology (P = 0.013) as did the presence of other major, concurrent medical problems (P = 0.065).

CONCLUSIONS:

In patients with laryngomalacia, GER was significantly associated with severe symptoms (a complicated clinical course), as was smoking in an infant's household and other significant medical problems.

• Authors: C Giannoni, M Sulek, E M Friedman, N O Duncan 3rd
• Journal: International journal of pediatric otorhinolaryngology (Int J Pediatr Otorhinolaryngol) Vol. 43 Issue 1 Pg. 11-20 (Feb 1998) ISSN: 0165-5876 [Print] Ireland
• PMID: 9596365 (Publication Type: Journal Article)

Topics

• Age of Onset
• Analysis of Variance
• Bronchoscopy
• Female
• Gastroesophageal Reflux (diagnosis, epidemiology, etiology)
• Humans
• Incidence
• Infant
• Infant, Newborn
• Laryngeal Diseases (complications, congenital, diagnosis)
• Laryngoscopy
• Larynx (pathology)
• Male
• Prospective Studies
• Risk Factors
• Severity of Illness Index
• Sex Distribution
• Statistics, Nonparametric
• Surveys and Questionnaires