HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Lymphoblastic transformation of myelodysplastic syndrome.

Abstract
Mielodysplastic syndromes (MDS) are clonal disorders of the hemopoietic stem cell. About one third of the cases terminate in an acute leukemia, usually acute myeloblastic leukemia. However, few cases of transformation into acute lymphoblastic leukemia (ALL) have been described. We present a case of refractory anemia that transformed into ALL two months after diagnosis and was successfully treated with conventional chemotherapy. Two years later a hyperfibrotic form of MDS was detected in the patient, that soon after terminated in acute megakaryoblastic leukemia. The course of MDS in the present case provides evidence that MDS can involve a pluripotent stem cell, presenting clonal evolution, documented by successive changes in its clinical and hematological features.
AuthorsC S Lima, C A de Souza, I A Cardinalli, I Lorand-Metze
JournalSao Paulo medical journal = Revista paulista de medicina (Sao Paulo Med J) 1997 Jul-Aug Vol. 115 Issue 4 Pg. 1508-12 ISSN: 1516-3180 [Print] Brazil
PMID9595816 (Publication Type: Case Reports, Journal Article)
Topics
  • Bone Marrow (pathology)
  • Female
  • Humans
  • Lymphocyte Activation
  • Middle Aged
  • Myelodysplastic Syndromes (complications, diagnosis, immunology)
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma (diagnosis, etiology, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: